Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/19/21 (What's New)

Summary

  • Attachment of HIV surface envelope protein gp120 to CD4 receptor is the first step in viral infection of the cell
  • Conformational change in gp120 enables binding to 1 of 2 beta-chemokine coreceptors, CCR5 or CXCR4
  • When HIV is bound to both CD4 and chemokine receptor, an additional conformational change allows viral envelope and host cell membrane to come into contact

Action required

Keywords: Initial Antiretroviral Therapy, Special Populations, Treatment Complications, Tropism

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