Agents Used in Antiretroviral Therapy
Summary
- Attachment of HIV surface envelope protein gp120 to CD4 receptor is the first step in viral infection of the cell
- Conformational change in gp120 enables binding to 1 of 2 beta-chemokine coreceptors, CCR5 or CXCR4
- When HIV is bound to both CD4 and chemokine receptor, an additional conformational change allows viral envelope and host cell membrane to come into contact
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