Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/9/19 (What's New)

Summary

  • Viral DNA may either lie latent or be transcribed into mRNA
  • Cells containing transcriptionally latent viral DNA are not susceptible to antiretroviral therapy, providing an important mechanism for persistence of infection during antiretroviral therapy
  • Transcription and translation of viral genome results in variety of proteins needed for mature HIV to replicate and infect other cells

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