Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/10/19 (What's New)

Summary

  • Etravirine is indicated in combination with other antiretroviral agents for treatment of HIV infection in treatment-experienced adult patients who have evidence of viral replication and resistance to an NNRTI and other antiretroviral agents[FDA Etravirine]
    • Major advantage of etravirine compared with first-generation NNRTIs is its activity against many NNRTI-resistant variants
    • K103N mutation alone has not been shown to compromise activity of etravirine

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