Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/20/20 (What's New)


    Efavirenz-Based Initial Therapy
    • There are currently 5 NNRTIs approved for first-line use in patients with HIV
    • Efavirenz, the standard-of-care first-line NNRTI for many years, is no longer included in recommended first-line regimens in guidelines, but remains a component of alternative first-line regimens[IASUSA ART; DHHS ART; EACS ART]
    • Efavirenz-based first-line therapy is not optimal for:
      Rilpivirine-Based Initial Therapy
        Doravirine-Based Initial Therapy
          Considerations for Choosing a First-line NNRTI

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