Key Principles and Recommended Regimens for First-line Antiretroviral Therapy
Summary
- There are currently 5 NNRTIs approved for first-line use in patients with HIV
- Efavirenz, the standard-of-care first-line NNRTI for many years, is no longer included in recommended first-line regimens in guidelines, but remains a component of alternative first-line regimens[IASUSA ART; DHHS ART; EACS ART]
- Efavirenz-based first-line therapy is not optimal for:
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