Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 10/5/18 (What's New)


  • There are currently 6 NNRTIs approved for use in HIV-infected patients
  • Efavirenz was for many years the standard-of-care first-line NNRTI
  • Efavirenz is no longer included in recommended first-line regimens in US guidelines, but remains a component of alternative first-line regimens[IAS-USA ART; DHHS ART; EACS ART]

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