Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • There are currently 5 NNRTIs approved for first-line use in patients with HIV
  • Efavirenz, the standard-of-care first-line NNRTI for many years, is no longer included in recommended first-line regimens in guidelines, but remains a component of alternative first-line regimens[IASUSA ART; DHHS ART; EACS ART]
  • Efavirenz-based first-line therapy is not optimal for:

    Action required