Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/20/20 (What's New)

Summary

  • There are currently 5 NNRTIs approved for first-line use in patients with HIV
  • Efavirenz, the standard-of-care first-line NNRTI for many years, is no longer included in recommended first-line regimens in guidelines, but remains a component of alternative first-line regimens[IASUSA ART; DHHS ART; EACS ART]
  • Efavirenz-based first-line therapy is not optimal for:

    Action required

    Keywords: Adherence, Biomedical Prevention, Drug-Drug Interactions, Dyslipidemia, Initial Antiretroviral Therapy, Pregnancy, Psychiatric Disorders, Treatment Complications, Women

    ©2020 Clinical Care Options, LLC. All Rights Reserved.

    The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.