Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 10/5/18 (What's New)


  • Lopinavir/ritonavir is the only coformulated ritonavir-boosted PI
    • May be administered once or twice daily in treatment-naive patients
  • Lopinavir/ritonavir was the gold standard for PI-based antiretroviral therapy for many years but has been supplanted by other PIs with better tolerability

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