Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • Recent investigations have studied newer agents as part of NRTI-sparing regimens in treatment-naive patients
  • The IAS-USA guidelines includes no NRTI-sparing as initial ART, but recognizes that they can produce comparable virological results as 3-drug regimens[IASUSA ART]
  • The DHHS guidelines now include dolutegravir/lamivudine as a recommended regimen for most people with HIV, except for individuals with HIV-1 RNA > 500,000 copies/mL, potential HBV coinfection, or those with no HIV genotype resistance testing results for reverse transcriptase

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