Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • Genotypic resistance testing for reverse transcriptase and protease mutations is recommended for all patients newly diagnosed with HIV infection, even if treatment is not immediately initiated[DHHS ART; IASUSA ART; EACS ART]
  • Resistance-associated mutations present at baseline may be associated with higher rates of virologic failure of those regimens, particularly for NNRTIs[Borroto-Esoda 2007; Kuritzkes 2008]

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