Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • Emtricitabine/tenofovir DF is associated with renal and bone effects
  • Nephrotoxicity is the most important adverse event associated with tenofovir DF treatment
    • Clinicians should monitor serum creatinine and creatinine clearance periodically for all patients receiving tenofovir DF and should be especially vigilant in patients with preexisting renal disease or risk factors for this condition

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