Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • Treatment with abacavir may lead to a potentially life-threatening HSR
    • HSR occurs in 5% to 8% of patients treated with abacavir[FDA Abacavir]
    • Risk for HSR is strongly linked to the presence of the HLA-B*5701 allele[Mallal 2008]

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