Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • The phase III STARTMRK trial compared raltegravir with efavirenz, both with emtricitabine/tenofovir DF, in 563 treatment-naive patients
  • At Week 48, the efficacy of raltegravir was noninferior to that of efavirenz, with 86% and 82%, respectively, achieving HIV-1 RNA < 50 copies/mL by intent-to-treat, noncompleter-equals-failure analysis[Lennox 2009]
  • At Week 240, raltegravir was superior to efavirenz with 71% and 61% of patients, respectively, achieving HIV-1 RNA < 50 copies/mL

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