Optimizing Adherence to Antiretroviral Therapy

  • Author: Nancy Reynolds, PhD, RN, C-NP, FAAN (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 3/21/18 (What's New)


  • Patterns and level of adherence associated with risk for viral rebound and resistance vary by viral fitness and antiretroviral drug and regimen characteristics
  • DHHS, IAS-USA, and EACS recommend a number of coformulated, once-daily, and other simplified treatment options for initial ART[DHHS ART; IAS-USA ART; EACS ART]
  • Simplified treatment regimens are effective, favored by patients and providers, and associated with better adherence,[Blaschke 2008; Ortiz 2008; Riddler 2008; van Dulmen 2007; Nachega 2014] yet, it may be difficult for some patients to maintain high levels of adherence even to simplified regimens

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Keywords: Adherence