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Additional Disclosure Information

The following faculty and staff have previously contributed to the content of this module and disclosed the following potential conflicts of interest:

John Delehanty, PhD, disclosed that he had served as a consultant for ArCuris GmbH at the time he contributed to this module.

Joel E. Gallant, MD, MPH, disclosed that he had received consulting fees from Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Japan Tobacco, Merck, Takara Bio, and ViiV; had served on advisory boards for Pfizer, RAPID Pharmaceuticals, Tibotec, and ViiV; had served on data and safety monitoring boards for Gilead Sciences, Koronis, and Sangamo; had received honoraria from Monogram Biosciences; and had received funds for research support from AbbVie, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, Roche, Sangamo, Vertex, and ViiV at the time he contributed to this module.

Elaine P. Seeskin had no real or apparent conflicts of interest to report as the time she contributed to this module.

Kimberly Y. Smith, MD, MPH, disclosed that she had served on advisory boards and as a consultant for Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Merck, Tibotec, and ViiV and had participated in speaker bureaus for GlaxoSmithKline and Merck at the time she contributed to this module.

Kathleen E. Squires, MD, disclosed that she had served on advisory boards for scientific purposes for Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, and ViiV; had served on advisory boards for marketing purposes for Gilead Sciences and Janssen; had served on advisory boards for Boehringer Ingelheim, GlaxoSmithKline, Koronis, Pfizer, Schering-Plough, Tobira, and Tibotec; had received funds for research support from BioCryst, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Koronis, Merck, Schering-Plough, Tibotec, and Vertex; and had received consulting fees from GlaxoSmithKline and Merck at the time she contributed to this module.

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inPractice Hepatology current certification period
Release Date: March 2, 2020
Expiration Date: March 1, 2021

Target Audience

This program is intended for physicians and other healthcare professionals involved in the medical management of patients with or at risk of viral hepatitis.

Goal:

The goal of this activity is to improve learners’ knowledge and competence regarding the clinical management of patients with viral hepatitis.

Learning Objectives:

At the conclusion of this activity, participants should be able to:

• Appropriately diagnose and manage treatment-naive patients with viral hepatitis, including using correct pretreatment evaluations, selection of regimen according to viral and patient factors and guideline recommendations, on-treatment monitoring, and goals of therapy
• Optimally manage treatment-experienced patients with viral hepatitis, including selecting the appropriate regimen depending on treatment history and viral genotype, optimizing patient adherence, and minimizing adverse events
• Implement appropriate management strategies for special populations of patients with viral hepatitis, including those with acute infection, cirrhosis, or end-stage renal disease; children; pregnant women and those of childbearing age; men who have sex with men, incarcerated persons, HIV-coinfected patients; and those who are candidates for, or recipients of, transplantations

Commercial Support

This program is supported by educational grants from AbbVie.

inPractice HIV current certification period
Release Date: September 26, 2019
Expiration Date: September 25, 2020

Target Audience

This activity is intended for physicians and other healthcare professionals involved in the management of patients with HIV.

Goal:

The goal of this activity is to provide a comprehensive clinical reference resource on the prevention, diagnosis, and treatment of HIV disease.

Learning Objectives:

At the conclusion of this activity, participants should be able to:

• Demonstrate an improvement in patient outcomes by applying information at the point of care
• Epidemiology and prevention: evaluate current demographic trends in HIV disease, modes of sexual and nonsexual transmission of HIV, and Centers for Disease Control and Prevention guidelines for implementing HIV testing, prevention, and infection control
• HIV-related basic science: Interpret the clinical significance of the HIV life cycle and natural history, virologic and immunologic aspects of disease pathogenesis, and factors associated with disease progression
• Clinical management: Integrate methods of HIV detection and diagnosis, patient history taking, syndromic evaluation for differential diagnosis, and health maintenance interventions into patient care; apply best practices in diverse aspects of patient care including issues in specific patient populations and coordination of care
• Disease manifestations: Manage the clinical presentation, diagnosis, treatment, and prophylaxis for the full range of opportunistic diseases, coinfections, and HIV-associated disorders that may occur in HIV-infected patients
• Initial antiretroviral therapy: Formulate state-of-the-art antiretroviral management strategies for treatment-naive patients, including attention to considerations when selecting regimens, monitoring and goals of therapy, and strategies for maximizing adherence
• Antiretroviral resistance: Appraise the clinical impact of antiretroviral resistance, including resistance assays and their interpretation, transmitted resistance, and patterns of emergent drug resistance associated with different regimens
• Treatment-experienced patients: Optimally manage treatment-experienced patients, including setting appropriate goals of therapy and selecting active agents when constructing new regimens
• Complications of antiretroviral therapy: Manage common antiretroviral toxicities and drug-drug interactions among antiretroviral agents and among antiretrovirals and concomitant agents

Commercial Support:

This program is supported by educational grants from Gilead Sciences and ViiV Healthcare.

For inPractice Hepatology and HIV

Physician Continuing Medical Education (for Point of Care CME activities)