Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

  • Plasma HIV-1 RNA (viral load) should be measured in all HIV-infected patients at baseline and regularly thereafter
  • Viral load is the most important indicator of response to antiretroviral therapy and a key surrogate marker for predicting likelihood of clinical progression[Marschner 1998; Thiébaut 2000]
    • Decrease in plasma viral load is a well-established predictor of improved clinical outcome[Murray 1999]
    • Assay Descriptions
      Clinically Relevant Thresholds
        Virologic Failure Definition and Relevance of Low-Level Viremia
          Issues Relating to Assay Format

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