Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

    Genotypic Assays
    • Commercial genotypic assays for NRTIs, NNRTIs, INSTIs, and PIs involve sequence analysis of the HIV-1 pol gene[Wensing 2014]
    • Genotypic assays that identify mutations associated with resistance to entry inhibitors are available, such as an HIV-1 gp41 envelope genotypic test for enfuvirtide resistance
    • Complex mutation patterns seen in multidrug-resistant patients can be difficult to interpret
      Phenotypic Assays for NRTIs, NNRTIs, PIs, Integrase Inhibitors, and Fusion Inhibitors
        Virtual Phenotype: NRTIs, NNRTIs, PIs
          Determining the Appropriate Resistance Test

          Action required