Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

  • Tropism tests assess coreceptor utilization among a viral population
  • HIV-1 may also be dual tropic (ie, may use either coreceptor), and some patients are infected with mixed HIV populations of CCR5- and CXCR4-tropic viruses
  • Maraviroc binds only to CCR5 receptors and should be used only in patients with CCR5-tropic infection
  • Phenotypic Tropism Assays
      Genotypic Tropism Assays
        Results of Genotype vs Phenotype in Predicting Response to Maraviroc
          When to Obtain Viral Tropism Tests

          Action required

          Keywords: Tropism