Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

  • Algorithms such as position-specific scoring matrices and geno2pheno have been developed to predict viral tropism utilizing V3 loop sequences[Soulie 2008]
    • These algorithms are highly concordant but may miss X4 or dual/mixed viruses
  • A panel of European experts on HIV genotyping, viral tropism, and antiretroviral therapy has recommended either phenotypic testing or a genotypic approach (with geno2pheno interpretation) to predict HIV tropism in antiretroviral-naive or -experienced patients[Vandekerckhove 2011]

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Keywords: Tropism