Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

Introduction

  • Scientific discoveries relating to the structure and function of HIV-1 have led to the development of tests to monitor HIV-infected patients
  • Use of laboratory tests in managing HIV infection is an evolving practice
  • Consensus guidelines are available that recommend the most appropriate use of individual tests

CD4+ Cell Count Monitoring

  • CD4+ cell count is an essential laboratory test used to measure immune status and monitor response to antiretroviral therapy[DHHS ART; IAS-USA ART]
  • Normal range of CD4+ cell counts is approximately 500-1500 cells/mm3
  • CD4+ cell percentage is generally more stable than absolute cell count

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