Management of Treatment-Experienced HIV-Infected Patients
Summary
- DHHS (Management Guidelines)[DHHS ART] and IAS-USA (Management Guidelines)[IAS-USA ART] define treatment goal as increasing disease-free survival by suppressing plasma HIV-1 RNA to undetectable levels
- Clinicians must identify active antiretroviral agents (Table) based on detailed treatment history and review of all drug-resistance testing results in the context of what treatment regimen the patient was taking at the time of testing
- Treatment-experienced patients have best chance of achieving viral suppression with 2—preferably 3—fully active drugs, possibly combined with select partially active drugs[Steigbigel 2010; Hardy 2008; Katlama 2010; Tashima 2015 ]
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