Management of Treatment-Experienced HIV-Infected Patients

  • Author: Eric S. Daar, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 7/16/19 (What's New)

Summary

  • DHHS (Management Guidelines)[DHHS ART] and IAS-USA (Management Guidelines)[IAS-USA ART] define treatment goal as increasing disease-free survival by suppressing plasma HIV-1 RNA to undetectable levels
  • Clinicians must identify active antiretroviral agents (Table) based on detailed treatment history and review of all drug-resistance testing results in the context of what treatment regimen the patient was taking at the time of testing
  • Treatment-experienced patients have best chance of achieving viral suppression with 2—preferably 3—fully active drugs, possibly combined with select partially active drugs[Steigbigel 2010; Hardy 2008; Katlama 2010; Tashima 2015 ]

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