Management of Treatment-Experienced HIV-Infected Patients

  • Author: Eric S. Daar, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 3/21/21 (What's New)


  • DHHS (Management Guidelines)[DHHS ART] and IAS-USA (Management Guidelines)[IAS-USA ART] define treatment goal as increasing disease-free survival by suppressing plasma HIV-1 RNA to undetectable levels
  • Clinicians must identify active antiretroviral agents (Table) based on detailed treatment history and review of all drug-resistance testing results in the context of what treatment regimen the patient was taking at the time of testing
  • Treatment-experienced patients have best chance of achieving viral suppression with 2—preferably 3—fully active drugs, possibly combined with select partially active drugs[Steigbigel 2010; Eron 2013b; Hardy 2010; Katlama 2010; Tashima 2015; Gandhi 2020]

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