Management of Treatment-Experienced HIV-Infected Patients

  • Author: Eric S. Daar, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 7/16/19 (What's New)

Summary

  • Clinical trial data defining the optimal management of patients experiencing treatment failure with first-line regimens consisting of NRTIs plus an INSTI are few
    • An extrapolation of data on virologic failure of first-line NNRTI-based regimens[La Rosa 2016; Boyd 2013; Paton 2014] suggests that patients could be effectively treated with NRTIs plus a ritonavir-boosted PI in the setting of first-line INSTI failure
  • In the absence of viral drug resistance, the emphasis should be on improving adherence to the original regimen

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