Management of Treatment-Experienced HIV-Infected Patients
Summary
- After assuring adherence and lack of drug–drug and drug–food interactions, it is important to assess whether the person has a fully active boosted PI available
- For those without a fully active boosted PI, genotypic scores and phenotypic clinical cutoffs have been established for many agents in long-standing drug classes to predict level of drug activity, including newer agents within these classes
- Agents from new drug classes such as entry inhibitors, post-attachment inhibitors, and INSTIs are assumed to be fully active in those who are naive to them[Lalezari 2003; Steigbigel 2008] Selecting Among Available Antiretrovirals
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