Management of Treatment-Experienced HIV-Infected Patients

  • Author: Eric S. Daar, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 7/16/19 (What's New)


  • CCR5 antagonists currently approved for use in patients without detectable CXCR4-using virus[Fätkenheuer 2008; Gulick 2008]
  • If previous tropism testing results show no CXCR4-tropic virus, repeat testing should be considered before initiating therapy with CCR5 antagonists
  • A subset of people who experience maraviroc failure without detectable CXCR4-using virus actually have true resistance to drug[Jubb 2009]

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