Management of Treatment-Experienced Patients With HIV
Summary
- CCR5 antagonists currently approved for use in patients without detectable CXCR4-using virus[Fätkenheuer 2008; Gulick 2008]
- If previous tropism testing results show no CXCR4-tropic virus, repeat testing should be considered before initiating therapy with CCR5 antagonists
- A subset of people who experience maraviroc failure without detectable CXCR4-using virus actually have true resistance to drug[Jubb 2009]
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