Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/18/21 (What's New)

Introduction

  • In clinical trials of antiretroviral-naive patients, the proportion of patients achieving undetectable HIV-1 RNA was approximately 90%[Sax 2017]
  • Most patients will likely continue treatment with the same antiretroviral regimen for many years
  • For some patients there are often important, nonvirologic reasons to modify their antiretroviral regimen, such as drug intolerance or the need to simplify the regimen

With currently available antiretroviral agents, it is possible to design simple and safe virologically suppressive HIV treatment regimens for patients across the spectrum of treatment experience, from antiretroviral naive to highly treatment experienced. In clinical trials of antiretroviral-naive patients, the proportion achieving undetectable HIV-1 RNA has been approximately 90%.[Sax 2017] ...

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Keywords: Switch Strategies