Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/18/21 (What's New)


  • Primary care providers should understand that modifying antiretroviral therapy in virologically suppressed patients should only be done for a good reason and must be managed with caution, ideally in consultation with an HIV expert
    • Reasons for changing therapy may include tolerability, toxicity, preservation of treatment options, or avoidance of drug–drug interactions (Table 1)
  • Goal of therapy modification in virologically suppressed patients is to correct the problem with current therapy (eg, toxicity, drug–drug interaction, regimen complexity) while maintaining virologic suppression

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