Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/18/21 (What's New)


  • Maintaining an undetectable HIV-1 RNA is certainly possible with most triple-drug and several 2-drug antiretroviral combinations in patients who do not harbor drug-resistant HIV strains
    • However, when a patient is infected with drug-resistant HIV, taking into account both current and archived antiretroviral resistance is very important in planning the new regimen
  • When there is uncertainty about earlier or archived resistance, it is generally not advisable to modify a suppressive ART regimen unless it is clear that the new regimen is likely to be at least as active against potential resistant virus as the current suppressive regimen

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