Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients
Summary
- A total of 24% of participants in the DRIVE-SHIFT trial,[Johnson 2019] which evaluated a switch to doravirine/lamivudine/tenofovir DF in virologically suppressed patients on stable ART for ≥ 6 months with no previous virologic failure or resistance to doravirine if they were on NNRTI-based regimens before the switch
- Among those who entered the study on regimens including an NNRTI, 94.3% vs 96.4%, respectively, reached the primary endpoint. Participants who had a history of NNRTI mutations—K103N, Y181C, or G190A—also had good results, with 90.9% of those who switched to doravirine/lamivudine/tenofovir DF and 100% who maintained their baseline regimen had HIV-1 RNA < 50 copies/mL at Week 48. No resistance to doravirine developed in either treatment group
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