Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 3/17/20 (What's New)

Summary

  • Studies evaluating switches in suppressed patients receiving stable lopinavir/ritonavir-based antiretroviral therapy switched to raltegravir found improvements in serum lipids
    • SWITCHMRK studies[Eron 2010] were stopped at Week 24 because of increased risk of virologic failure; however, the SPIRAL study[Martínez 2010] did not demonstrate such a difference

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Keywords: Adherence, Cardiovascular Disease, Dyslipidemia, Fat Perturbations, Switch Strategies, Treatment Complications

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