Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/18/21 (What's New)



  • In clinical trials of antiretroviral-naive patients, the proportion of patients achieving undetectable HIV-1 RNA was approximately 90%[Sax 2017]
  • Most patients will likely continue treatment with the same antiretroviral regimen for many years
  • For some patients there are often important, nonvirologic reasons to modify their antiretroviral regimen, such as drug intolerance or the need to simplify the regimen

Reasons for Modifying Antiretroviral Therapy

  • According to the US Department of Health and Human Services antiretroviral therapy guidelines panel, the fundamental tenet of changing antiretroviral therapy in the setting of virologic suppression is the maintenance of viral suppression without compromise of future treatment options
  • International antiretroviral therapy guidelines outline specific criteria for patients on suppressive antiretroviral therapy to be considered for treatment modification[DHHS ART] ...

    Action required