inPractice® - PIs and Dyslipidemia

Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease

Authors: Judith S. Currier, MD, MSc; Risa Hoffman, MD, MPH (More Info)
Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
Last Reviewed: 10/10/18 (What's New)

Summary

PI-based therapy is generally associated with hypertriglyceridemia and increases in LDL^{[Calza 2004]}
Lipid effects vary across the PI class
- Ritonavir increases triglycerides and very low LDL, and reduces HDL^{[Purnell 2000]}

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Keywords: Dyslipidemia, Treatment Complications