Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease
Summary
- Fibrates have been shown to decrease triglycerides by 30% to 50% in HIV-uninfected patients and to increase HDL by 6% to 15%[Steiner 2005]
- Fibrates are somewhat effective for PI-associated hypertriglyceridemia and may be considered in patients with triglycerides > 500 mg/dL (> 27.75 mmol/L)
- Combination of gemfibrozil and statins should be avoided because of high rates of muscle toxicity[Jones 2005a; Davidson 2007]
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