Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease

  • Authors: Judith S. Currier, MD, MSc; Risa Hoffman, MD, MPH (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/10/18 (What's New)

Summary

  • Fibrates have been shown to decrease triglycerides by 30% to 50% in HIV-uninfected patients and to increase HDL by 6% to 15%[Steiner 2005]
  • Fibrates are somewhat effective for PI-associated hypertriglyceridemia and may be considered in patients with triglycerides > 500 mg/dL (> 27.75 mmol/L)
  • Combination of gemfibrozil and statins should be avoided because of high rates of muscle toxicity[Jones 2005a; Davidson 2007]

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