Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease

  • Authors: Judith S. Currier, MD, MSc; Risa Hoffman, MD, MPH (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/10/18 (What's New)

Summary

  • Fibrates have been shown to decrease triglycerides by 30% to 50% in HIV-uninfected patients and to increase HDL by 6% to 15%[Steiner 2005]
  • Fibrates are somewhat effective for PI-associated hypertriglyceridemia and may be considered in patients with triglycerides > 500 mg/dL (> 27.75 mmol/L)
  • Combination of gemfibrozil and statins should be avoided because of high rates of muscle toxicity[Jones 2005a; Davidson 2007]

Action required

Keywords: Cardiovascular Disease, Dyslipidemia, Treatment Complications

©2020 Clinical Care Options, LLC. All Rights Reserved.

The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.