Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • Annual incidence of osteonecrosis as compared with osteopenia in HIV-infected patients is very low, ranging from 0.08% to 1.30%
  • Prominent risk factors include corticosteroid use, alcoholism, dyslipidemia, and hypercoagulable states
    • ARV agents do not appear to be involved epidemiologically in its development

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