Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • Clinically asymptomatic hyperlactatemia much more common than lactic acidosis
  • Relationship between chronic asymptomatic hyperlactatemia and severe lactic acidosis is uncertain[Boxwell 1999]
    • Associated with increased rates of lactate production, in part derived from adipose tissue[Johnson 2004; Sekhar 2002]

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