Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • FRAM study was a multicenter, prospective, cross-sectional investigation to compare body fat content/distribution and metabolic measurements in HIV-infected and HIV-uninfected men and women
    • Included 425 HIV-infected men,[Bacchetti 2005]183 HIV-infected women,[FRAM 2006] and 292 uninfected controls
    • Demonstrated that lipoatrophy and lipohypertrophy are independent phenomena in both men and women

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