Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


    Prevention of Lipoatrophy
    • Use of the thymidine analogue NRTIs that are associated with lipoatrophy has waned in favor of NRTIs that are more tolerable, such as tenofovir DF, abacavir, and tenofovir AF
    • Many clinicians agree that prevention of lipoatrophy is a better practice than trying to reverse the process once it is clinically evident
    Antiretroviral Switch Strategies
    • Several studies have explored the efficacy of switching from a thymidine analogue NRTI to an alternative NRTI to try to reverse lipoatrophy[Moreno 2009]
      Pharmacologic Management
        Reconstructive Surgery

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