Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • Several studies have evaluated the effects of thiazolidines with mixed results, but no effective clinical intervention
  • Uridine, a precursor molecule for all pyrimidines, has been shown to reverse lipoatrophyin a small, randomized clinical trial,[Sutinen 2007] but subsequent larger trials have failed to replicate these results[McComsey 2010a; McComsey 2012]

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