Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


    Impact of Antiretroviral Choice
    • No prospective studies have demonstrated evidence of significant lipohypertrophy in patients who have started on contemporary ART regimens
    • Studies on managing lipohypertrophy have shown no evidence that it can be avoided through strategic choice of ART
    • Results of NRTI modification studies are divergent:
      Lifestyle Modification
        Pharmacologic Management
          Insulin Sensitizers
            Human Growth Hormone
              Human Growth Hormone–Releasing Factor
                Leptin and Other Interventions for Lipohypertrophy

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