Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • No prospective studies have demonstrated evidence of significant lipohypertrophy in patients who have started on contemporary ART regimens
  • Studies on managing lipohypertrophy have shown no evidence that it can be avoided through strategic choice of ART
  • Results of NRTI modification studies are divergent:

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