Management of Bone Disease and Body Composition Changes
Summary
- Insulin Sensitizers
- Studies have shown decreases in waist circumference with metformin[Hadigan 2000] and increases in limb fat with pravastatin[Mallon 2006] in HIV-infected patients
- Major emphasis for management of lipohypertrophy has revolved around the use of human growth hormone and the human growth hormone–releasing factor analogue tesamorelin
- Rationale for using human growth hormone is the known inverse relationship between visceral adipose tissue and secretion of human growth hormone[Veldhuis 1995]
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