Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • Studies have shown decreases in waist circumference with metformin[Hadigan 2000] and increases in limb fat with pravastatin[Mallon 2006] in HIV-infected patients
  • Major emphasis for management of lipohypertrophy has revolved around the use of human growth hormone and the human growth hormone–releasing factor analogue tesamorelin

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