Management of Bone Disease and Body Composition Changes
Summary
- SMART study compared the effects of continuous ART vs CD4+ cell count–directed, intermittent ART on bone density in 1 substudy of 214 subjects[Grund 2009]
- Significantly more patients receiving continuous ART had decreased bone density compared with patients receiving intermittent ART
- In addition, significantly more patients receiving continuous ART reported grade 4 fractures compared with those receiving intermittent therapy
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Keywords: Bone Disease , Treatment Complications