ART has been associated with markedly diminished morbidity and mortality[Palella 1998]
Development of treatment-related complications diminishes the therapeutic benefits of ARVs
Several host and other confounding factors related to treatment-associated complications have been identified
Host factors: age, sex, race, family history, BMI, diet, exercise, tobacco use
Disease factors: duration, severity of immune depletion, magnitude of immune reconstitution
Other factors: difficulty obtaining clinically relevant measurements, difficulty distinguishing HIV effects from those of normal aging
Although the prevalence and severity of treatment-associated toxicities have decreased in the developed world, the incidence is higher in the developing world, primarily because of the use of older ARVs and less-aggressive treatment of comorbidities[Subbaraman 2007; Murphy 2007]...
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