Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)


  • Antiretrovirals undergo pharmacokinetic transformation during absorption, distribution, metabolism, and elimination
  • Most clinically relevant drug interactions involving antiretrovirals occur because of alterations in drug-metabolizing enzyme activity
  • Renal elimination is not a common cause of antiretroviral drug interactions

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