Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • CYP 450 enzyme system can be enhanced (induction) or suppressed (inhibition); antiretrovirals are involved in both processes (Table 1)
    • Induction leads to increased enzyme production, enhancing metabolism of medications that are substrates of CYP 450 enzymes, with resultant decreases in the concentration of these substrates
    • Inhibition leads to decreased metabolism of CYP 450 enzyme substrates, with resultant increased concentrations of these substrates

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