Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Several medications in each antiretroviral class are affected by drug transporters present in multiple cell lines
- Effect of the P-gp has been best characterized to date
- Many antiretrovirals are substrates for P-gp and can be transported across cellular membranes by this protein, with potential for clinically relevant drug interactions[DHHS ART; DuBuske 2005; Cianfriglia 2009; Becker 2003; Vourvahis 2010; Reese 2013]
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Keywords: Drug-Drug Interactions, Pharmacokinetics