Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • Several medications in each antiretroviral class are affected by drug transporters present in multiple cell lines
    • Effect of the P-gp has been best characterized to date
  • Many antiretrovirals are substrates for P-gp and can be transported across cellular membranes by this protein, with potential for clinically relevant drug interactions[DHHS ART; DuBuske 2005; Cianfriglia 2009; Becker 2003; Vourvahis 2010; Reese 2013]

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