inPractice® - Drug Transporters

Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Summary

Several medications in each antiretroviral class are affected by drug transporters present in multiple cell lines
- Effect of the P-gp has been best characterized to date
Many antiretrovirals are substrates for P-gp and can be transported across cellular membranes by this protein, with potential for clinically relevant drug interactions^{[DHHS ART; DuBuske 2005; Cianfriglia 2009; Becker 2003; Vourvahis 2010; Reese 2013]}

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Keywords: Drug-Drug Interactions, Pharmacokinetics