inPractice® - Antiretrovirals and Antacids

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Caution should be advised when antacids are used with atazanavir (with or without ritonavir), fosamprenavir, or tipranavir/ritonavir
- Patients should be instructed to take the PI either 2 hours before or 1 hour after the antacid (Management Guidelines)^{[DHHS ART]}
Antacids should be administered at least 2 hours before or 4 hours after receiving rilpivirine,^{[FDA Rilpivirine]} emtricitabine/rilpivirine/tenofovir DF,^{[FDA Emtricitabine/Rilpivirine/Tenofovir]}or emtricitabine/rilpivirine/tenofovir AF^{[FDA Emtricitabine/Rilpivirine/TAF]}