inPractice® - Fosamprenavir and Acid-Reducing Agents

Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Summary

Fosamprenavir must be given with ritonavir when used with a H2RA, and doses of the H2RA and fosamprenavir should be separated
PPIs have not demonstrated significant effects on fosamprenavir concentrations^{[Shelton 2006]}

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Keywords: Drug-Drug Interactions, Pharmacokinetics