Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Inhibitors of CYP 2D6, such as ritonavir and cobicistat, should be coadministered with chlorpromazine and thioridazine with extreme caution
- DHHS guidelines specifically caution about potential increases in thioridazine concentrations when coadministered with cobicistat/elvitegravir/emtricitabine/tenofovir DF, cobicistat/elvitegravir/emtricitabine/tenofovir AF, atazanavir/cobicistat, darunavir/cobicistat, or any cobicistat-boosted or ritonavir-boosted PI[DHHS ART]
- However, thioridazine can be coadministered with the NNRTIs efavirenz, etravirine, and nevirapine with monitoring of the antipsychotic due to possible concentration decreases
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