Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Cobicistat/elvitegravir/emtricitabine/tenofovir DF and cobicistat/elvitegravir/emtricitabine/tenofovir AF should not be coadministered with lovastatin or simvastatin[FDA COBI/EVG/TDF/FTC; FDA COBI/EVG/TAF/FTC]
- Titrate carefully from the lowest starting dose when coadministering cobicistat/elvitegravir/emtricitabine/tenofovir DF with atorvastatin, not to exceed 20 mg/day[FDA COBI/EVG/TDF/FTC; DHHS ART]
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Keywords: Drug-Drug Interactions, Pharmacokinetics