inPractice® - Isavuconazole and NNRTIs and PIs

Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/3/19 (What's New)

Summary

Isavuconazole has potential for drug interactions with PIs and NNRTIs^{[DHHS ART]}
- Exposure may be increased when used with PIs, and drug concentrations, response, and toxicity should all be monitored
- Exposure may be decreased when used with NNRTIs, and dose adjustments may be necessary

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Keywords: Drug-Drug Interactions, Pharmacokinetics