inPractice® - Fluconazole and NNRTIs and PIs

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Fluconazole has least potential for drug interactions with antiretrovirals of azole antifungals with no significant effect observed or expected in combination with most boosted PIs
- Fluconazole increases tipranavir, so doses of fluconazole less than 200 mg recommended when coadministered with tipranavir/ritonavir
Fluconazole increases concentrations of nevirapine and etravirine and is anticipated to increase the concentration of rilpivirine^{[DHHS ART; FDA Rilpivirine]}