Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Fluconazole has least potential for drug interactions with antiretrovirals of azole antifungals with no significant effect observed or expected in combination with most boosted PIs
- Fluconazole increases tipranavir, so doses of fluconazole less than 200 mg recommended when coadministered with tipranavir/ritonavir
- Fluconazole increases concentrations of nevirapine and etravirine and is anticipated to increase the concentration of rilpivirine[DHHS ART; FDA Rilpivirine]
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Keywords: Drug-Drug Interactions, Pharmacokinetics